Beilstein J. Org. Chem.2018,14, 1769–1777, doi:10.3762/bjoc.14.151
as the competence regulon, is centered on the competencestimulatingpeptide (CSP, Figure 1). S. pneumoniae utilizes the regulon to become competent and acquire antibiotic resistance from the environment, initiate its attack on the human host through virulence factor production, and protect itself
significant attention as a potential antivirulence alternative to traditional antibiotics. Streptococcus pneumoniae, a notorious human pathogen responsible for a variety of acute and chronic infections, utilizes the competence regulon and its associated signaling peptide, the competencestimulatingpeptide
stimulatingpeptide (CSP); protein–peptide interactions; quorum sensing; Streptococcus pneumoniae; structure–activity relationships (SAR); Introduction
Quorum sensing (QS), a cell-density mechanism utilized by bacteria to assess their population density through the detection of diffusible signal molecules
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Graphical Abstract
Figure 1:
The competence regulon QS circuitry in S. pneumoniae. ComC is processed and secreted by ComAB as th...